SRM Panels


Our Established SRM Panels
We have established human exploratory panels in urine, CSF, and blood plasma.

Tissue Number of proteins in the panel
CSF 300
Urine 400
Plasma 200

We also have several human disease panels ranging from neurodegenerative diseases to oncology, to diagnose a number of diseases based on the presence of known biomarkers.

Disease Panel Number of proteins in the panel
Neurodegenerative disease 150
Serpin 25
Kidney disease 30
Oncology 217
Arthritis 85
Cardiovascular 65
Inflammation 50
SMA 60
Ghrelin 4
Hepcidin 3
Infection and host response (JCV and HCV) 25

We can also develop high quality custom SRM panels upon request. For a small panel of proteins, assay development only takes several days for a fast turnaround time. The assay will be fully tested in real biological matrices, and biomarker and pharmacokinetic panels can be combined. Please contact us for more information

Our Neurodegenerative Disease SRM Panel
Neuro-SRM-150 panel Results Comments
Protein Numbers 150 128 of them are above the detection limit in the tested healthy CSF samples
Sensitivity: Av. LOD (ng/mL) 3.1 range from 0.04 to 50.11 ng/mL
Sensitivity: Av. LLOQ (ng/mL) 10.0 range from 0.08 to 154.22 ng/mL
Reproducibility: Av. CV% (LC-SRM) 7.8 Proteins with lower concentrations tend to have higher CVs
Reproducibility: Av. CV% (Entire process) 11.9 Proteins with lower concentrations tend to have higher CVs
Throughput: min/sample/panel (min) 30
Throughput: samples/week/instrument ~300 With a single injection
Sample amount: µL/injection 10 to 20
Dynamic Range: Order of Magnitude 3.7 range from 2.1 to 5.1

Selected Neurodegenerative Disease Panel Proteins
MS - Multiple Sclerosis
AD - Alzheimer's Disease
PD - Parkinson's Disease
ALS - Amyotrophic Lateral Sclerosis

Protein Biomarker Candidates MS AD PD ALS
alpha-1-B glycoprotein X X X
alpha-2-macroglobin X X X
actin, beta X X
angiotensinogen X X X
adherens junctions associated protein 1 X X
apolipoprotein A-I X X X
apolipoprotein D X X X
apolipoprotein E X X X X
beta-2-glycoprotein I X X X
beta-amyloid protein 42 X
amyloid beta (A4) (Soluble APP) X
alpha-2-glycoprotein 1, zinc-binding X
beta-2-microglobulin X X X X
complement C3 X X X X
complement component 4A X X
complement component 4B X X
cell growth regulator with EF-hand domain 1 X X
chromogranin A X X X X
chromogranin B X X X X
YKL-40 X X
clusterinX X X
beta-Ala-His dipeptidase X X X
contactin 1 X X X
cochlin X X
ceruloplasmin XX XX
cystain CX X X X
dystroglycan 1 X
EGF-containing fibulin-like extracellular matrix protein 1 X
fibrinogen beta chain X X
fibrinogen gamma chain X X
vitamin D binding proteinX X X
glial fibrillary acidic protein X X
golgin B1, golgi integral membrane protein X X
gelsolinX X X
probable E3 ubiquitin-protein ligase HERC4 X X
haptoglobin-related protein; haptoglobin X X
insulin-like growth factor binding protein 5 X X
interleukin-18 X
interleukin 1 receptor, type II X
EF-hand domain-containing protein KIAA0494 X X
kallikrein-related peptidase 6 X X X
microtubule-associated protein tau
X
microtubule-associated protein tau (phospho) X
sodium leak channel, non-selective X X
neural cell adhesion molecule 1X X X X
neuronal pentraxin receptorX X X
neuronal cell adhesion molecule X
neurexin 1 X X
teneurin-3 X X
orosomucoid1X X X
proprotein convertase subtilisin/kexin type 1 inhibitor X X
polymeric immunoglobin receptor X X
prostaglandin D2 synthaseX X
retinol binding protein 4 X X X
serum amyloid A2 X X
alpha-1-antitrypsin X X
pigment epithelium-derived factor X X X X
superoxide dismutase 1, soluble X X X
SPARC-like protein 1X X X
transferrinX X X X
transthyretin X X X X
14-3-3 protein theta X

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